The standard by which novel spin traps are evaluated is PBN, (N-tert-butyl-alpha-phenyl nitrone) which has been shown to extend the lives of list of major casinos in las vegas experimental animals.
Similarly, these agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite.
Unfortunately, VC investors are a nervous lot who read the patent literature.
For a summary of such diseases and pathogenic processes, read my review article ".The archetype nitrone drug, PBN, uniquely extends maximum lifespan in experimental animals.However, while my patents jouer au machines a sous gratuites 2012 were pending, reseachers with Centaur Pharmaceuticals applied for similar ones.Although our patents have previously prevented their marketing for skin antiaging, topical spin traps have generated much excitement as age-defying cosmeceuticals and skin care products.Antioxidants have become one of the cornerstones of any health maintenance and longevity program.While nominally for topical use, these patents also grant general utility for "ameliorating a cellular dysfunction of a tissue".Moreover, at this point all further costs were assumed by AstraZeneca, along with a 4,500,000 milestone payment to Centaur.Floyd.A.; Life Sci 1999; 65 (18-19 1893-9 a) Expression of cytokines and activation of transcription factors in rats and their inhibition by PBN.Infringement only begins when a drug company applies for FDA approval- here, not before 2006.A major advance has been the development of anti-dmpo antibodies by Mason's group, allowing study of spin trapping reactions by a simple immuno-based techniques.It has recently been shown that they exert this benefit by altering signal transduction pathways and reducing systemic inflammation, one of the primary culprits associated with the chronic degenerative diseases of aging.My IP aside, this did not exactly correspond to what Centaur said.Recent evidence suggests that this reaction may play a crucial role in a wide range of degenerative diseases.The method is based on the addition of a compound (the spin trap) to the transient radical species.The disulfonyl derivative of PBN ( phenybutylnitrone NXY059 or "Cerovive" (TM) is now in phase-3 clinical trials for stroke at Astrazeneca.
175-195 (1984) which is hereby incorporated herein by reference; and the like." Click.
The most commonly used spin traps are alpha-phenyl N-tertiary-butyl nitrone (PBN) and 5,5-dimethyl-pyrroline N-oxide (dmpo).
Spin Traps were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes that can be measured by a variety of techniques.1 They are frequently used to measure the efficacy of other antioxidants.